U.Tor.Prof.D J A JENKINS: "GLYCAEMIC INDEX"Can Nutrition Soc.meeting 11 Jan,2014 HYATT REGENCY

David J.A. Jenkins, BM,BCh (Oxon.1971),M.D., Ph.D., D.Sc. Professor Canada Research Chair in Nutrition and Metabolism Department of Nutritional Sciences Director, Risk Factor Modification Centre, St. Michael's Hospital Ph: 416.978.4752 Fax: 416.978.5310 cyril.kendall@utoronto.ca Research: The ultimate goal of our research team is to elucidate the potential of diet to prevent and treat chronic diseases; primarily heart disease, cancer and diabetes. Our research is clinically based. Dietary trials allow us to also assess mechanisms in vivo by which diet and/or its components alter risk for disease. We have spent considerable time assessing the glycemic index of foods, and have identified legumes and traditional methods of processing as producing a low glycemic index (eg. white pasta - low vs. white bread - high) We have and continue to carry out research on vegetable proteins and their potential health benefits eg. soy, gluten, and other cereal and vegan proteins. Most recently we have started to combine foods with cholesterol lowering actions (soy, viscous fibers, oats, barley, plant sterols and nuts - almonds) in a single diet to lower serum cholesterol. We have demonstrated that early statin-like effects can be achieved under highly controlled conditions. In the real world this dietary approach has a somewhat dampened level of efficacy, but remains a highly effective dietary approach to cholesterol reduction. We continue to carry out studies on low glycemic index diets, and the quest to find new low glycemic index foods continues. We also work in collaboration with the food industry on a diverse spectrum of food products and food components ranging from macronutrients to phytochemicals. Selected publications: Jenkins, DJA. Kendall CWC. Faulkner DA. Nguyen T. Kemp T. Marchie A. Wong JM. de Souza R. Emam A. Vidgen E. Trautwein EA. Lapsley KG. Holmes C. Josse RG. Leiter LA. Connelly PW. Singer W. Assessment of the longer-term effects of a dietary portfolio of cholesterol-lowering foods in hypercholesterolemia.American Journal of Clinical Nutrition. 83(3):582-91, 2006 Mar. Jenkins, DJA. Kendall CWC. Marchie A. Faulkner DA. Wong JMW. De Souza R. Emam A. Parker TL. Vidgen E. Trautwein EA. Lapsley KG. Josse RG. Leiter LA. Singer W. Connelly PW.Direct comparison of a dietary portfolio of cholesterol-lowering foods with a statin in hypercholesterolemic participants.American Journal of Clinical Nutrition. Vol. 81(2)(pp 380-387), 2005. Jenkins, DJA. Kendall CWC. Marchie A. Faulkner DA. Josse AR. Wong JMW. de Souza R. Emam A. Parker TL. Li TJ. Josse RG. Leiter LA. Singer W. Connelly PW. Direct comparison of dietary portfolio vs statin on C-reactive protein.European Journal of Clinical Nutrition. Vol. 59(7)(pp 851-860), 2005. Jenkins, DJA. Kendall CW. Marchie A. Faulkner DA. Wong JM. de Souza R. Emam A. Parker TL. Vidgen E. Lapsley KG. Trautwein EA. Josse RG. Leiter LA. Connelly PW. Effects of a dietary portfolio of cholesterol-lowering foods vs lovastatin on serum lipids and C-reactive protein.JAMA. 290(4):502-10, 2003 Jul 23. Jenkins, DJA. Kendall CW. D'Costa MA. Jackson CJ. Vidgen E. Singer W. Silverman JA. Koumbridis G. Honey J. Rao AV. Fleshner N. Klotz L. Soy consumption and phytoestrogens: effect on serum prostate specific antigen when blood lipids and oxidized low-density lipoprotein are reduced in hyperlipidemic men.Journal of Urology. 169(2):507-11, 2003 Feb. Jenkins, DJA. Kendall CW. Marchie A. Parker TL. Connelly PW. Qian W. Haight JS. Faulkner D. Vidgen E. Lapsley KG. Spiller GA. Dose response of almonds on coronary heart disease risk factors: blood lipids, oxidized low-density lipoproteins, lipoprotein(a), homocysteine, and pulmonary nitric oxide: a randomized, controlled, crossover trial. Circulation. 106(11):1327-32, 2002 Sep 10. Jenkins, DJA. Kendall CWC. Augustin LSA. Martini MC. Axelsen M. Faulkner D. Vidgen E. Parker T. Lau H. Connelly PW. Teitel J. Singer W. Vandenbroucke AC. Leiter LA. Josse RG. Effect of wheat bran on glycemic control and risk factors for cardiovascular disease in type 2 diabetes.Diabetes Care. Vol. 25(9)(pp 1522-1528), 2002. Jenkins, DJA. Kendall CW. Jackson CJ. Connelly PW. Parker T. Faulkner D. Vidgen E. Cunnane SC. Leiter LA. Josse RG. Effects of high- and low-isoflavone soyfoods on blood lipids, oxidized LDL, homocysteine, and blood pressure in hyperlipidemic men and women.American Journal of Clinical Nutrition. 76(2):365-72, 2002 Aug. Jenkins, DJA. Kendall CW. Connelly PW. Jackson CJ. Parker T. Faulkner D. Vidgen E. Effects of high- and low-isoflavone (phytoestrogen) soy foods on inflammatory biomarkers and proinflammatory cytokines in middle-aged men and women. Metabolism: Clinical & Experimental. 51(7):919-24, 2002 Jul. Jenkins, DJA. Kendall CW. Vuksan V. Vidgen E. Parker T. Faulkner D. Mehling CC. Garsetti M. Testolin G. Cunnane SC. Ryan MA. Corey PN. Soluble fiber intake at a dose approved by the US Food and Drug Administration for a claim of health benefits: serum lipid risk factors for cardiovascular disease assessed in a randomized controlled crossover trial. American Journal of Clinical Nutrition. 75(5):834-9, 2002 May.