CONGRESS PRESIDENT:
McMaster U.Prof. of Medicine (Thrombosis service) Sam SCHULMAN MD (Stockholm Karolinska Institute 1977) FRCPC (Int.Med + Haematology 2004).
7,500 attendees.
For Community physicians major advance is use of DIRECT INHIBITORS OF ACTIVATED FACTOR X for acute & extended duration treatment for Pulmonary embolism ,Deep vein thrombosis.+ Atrial fibrillation.
HISTORY( Wikipedia)
Spellman GG Jr., HL Nossel (April 1971). "Anticoagulant activity of dog hookworm." Am J Physiology 222:922-927.
A naturally occurring inhibitor of factor Xa was first reported in
1971 by Spellman et al. from the dog hookworm. In 1987, Tuszynski et al.
discovered antistasin, which was isolated from the extracts of Mexican leech, Haementeria officinalis. Soon after this, another naturally occurring inhibitor, tick anticoagulant peptide (TAP) was isolated from the extract of tick Ornithodoros moubata.[7]
APIXABAN( ELIQUIS) Pfizer & Bristol-Myers Squibb
EDOXABAN ( SAVAYSA) Daiichi Sankyo
RIVAROXABAN( XARELTO) Bayer.
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HAEMOPHILIA A can be treated with PROPHYLACTIC INFUSIONS OF RECOMBINANT FACTOR VIII . REDUCES JOINT DAMAGE.. CAN COST UP TO $1-MILLION / YEAR.
