A FORUM on ONTARIO MEDICINE: business and professional Information from various contributors edited by Dr.Alex Franklin MBBS(Lond.)Dip.Phys.Med(UK) DPH & DIH(Tor.)LMC(C)FLex(USA).Fellow Med.Soc.London, Liveryman of London Society of Apothecaries. Freeman of City of London. Member Toronto Faculty club & Toronto Medico-Legal society.
13 Feb 2014
SERUM FREE LIGHT CHAIN ANALYSIS (NOT PAID BY OHIP if orded by GPs & General Medical Clinics)
"BINDING SITE FREELIGHT" serum free light chain analysis
Now available PRIVATELY by Gamma Dynacare laboratories.
Provided free by OHIP at selected Oncology clinics.
Freelite™ Serum Free Light Chain Assays
(UK) Freelite™ is a major breakthrough for the detection and monitoring of Multiple MyelomaFreelite Logo (MM) and other B-cell dyscrasia. Freelite™ assays were developed by Binding Site to measure free lambda and free kappa immunoglobulin light chains. Our expertise in the manufacture of antibodies has enabled us to provide a quantifiable, highly specific, automatable free light chain assay for serum.
Significant clinical evidence indicates the benefit of Freelite™ serum free light chain assays in initial screening for monoclonal gammopathies. Other benefits include the identification of AL amyloidosis and Nonsecretory MM patients missed by conventional electrophoretic methods, use as a prognostic indicator for progression in myeloma, for risk stratification of MGUS patients, and rapid evaluation of treatment efficacy.
Freelite™ is a sensitive, specific marker of kappa and lambda free light chains (FLC) in serum and provides quantitative measurement of:
Free kappa in serum
Free lambda in serum
The serum free kappa/free lambda ratio (κ/λ)
The serum free light chain ratio is a strong indicator of monoclonality and is valuable for distinguishing monoclonal from polyclonal diseases.
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Important to have private insurance. Quebec better than Ontario with respect to paying for advanced tests and expensive medication. Long waits at Toronto Princess Margaret Cancer Hosp 3-4 hours. Also PMH "guidelines" limit number of visits. Catastrophic Insurance provides at least $250,000 and allows for PRIVATE North American treatment @ Royal Victoria,Montreal; Dana-Farber,Boston; Scottsdale Mayo,Ariz. Difference of PRIVATE vs STATE medicine: In PRIVATE medicine SPECIALIST(S) dictates management. In STATE medicine patients are used in trials & to train Junior doctors.. Read 1967 M.H. Pappworth FRCP(Lond) "HUMAN GUINEA PIGS:"
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